Green chemistry metrics: a comparative evaluation of dimethyl carbonate, methyl iodide, dimethyl sulfate and methanol as methylating agents
Green chemistry metrics (atom economy and mass index) have been applied to compare a total of 33 procedures for the synthesis of anisole, 2-phenylpropionitrile, and N-methylaniline, carried out with four methylating agents such as dimethyl carbonate, dimethyl sulfate, methyl iodide and methanol. The non toxic DMC proved to be the best reagent among those considered.
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